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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
FRK
All Species:
20.61
Human Site:
S389
Identified Species:
37.78
UniProt:
P42685
Number Species:
12
Phosphosite Substitution
Charge Score:
-0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P42685
NP_002022.1
505
58254
S389
D
N
E
D
I
Y
E
S
R
H
E
I
K
L
P
Chimpanzee
Pan troglodytes
XP_518702
505
58217
S389
D
N
E
D
I
Y
E
S
R
H
E
I
K
L
P
Rhesus Macaque
Macaca mulatta
XP_001112190
505
58228
S389
D
N
E
D
I
Y
E
S
K
H
E
I
K
L
P
Dog
Lupus familis
XP_539091
505
57709
I390
F
K
V
D
N
E
D
I
Y
E
S
K
H
D
I
Cat
Felis silvestris
Mouse
Mus musculus
Q922K9
512
58825
S396
D
N
E
D
I
Y
E
S
K
H
E
I
K
L
P
Rat
Rattus norvegicus
Q62662
506
58147
S390
D
N
E
D
I
Y
E
S
K
H
E
I
K
L
P
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Q02977
536
59984
A421
I
E
D
N
E
Y
T
A
R
Q
G
A
K
F
P
Frog
Xenopus laevis
P13406
537
60828
A422
I
E
D
N
E
Y
T
A
R
Q
G
A
K
F
P
Zebra Danio
Brachydanio rerio
XP_695937
480
54879
A363
N
E
D
N
V
Y
E
A
K
E
G
T
K
F
P
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9V9J3
517
59051
A402
I
K
E
D
E
Y
E
A
R
V
G
A
R
F
P
Honey Bee
Apis mellifera
XP_396043
451
51726
R337
K
E
D
E
Y
E
A
R
I
G
A
R
F
P
I
Nematode Worm
Caenorhab. elegans
NP_493502
507
57512
A391
M
K
E
N
E
Y
E
A
R
T
G
A
R
F
P
Sea Urchin
Strong. purpuratus
NP_001135852
530
59779
S414
I
K
D
E
I
Y
E
S
H
V
G
A
K
F
P
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.4
96.6
80.5
N.A.
88.6
88.3
N.A.
N.A.
48.5
48.4
60.5
N.A.
56.8
51.6
50.4
56.6
Protein Similarity:
100
99.8
98
87.7
N.A.
92.9
93
N.A.
N.A.
64.7
64.2
74
N.A.
73.3
67.1
69.4
70.5
P-Site Identity:
100
100
93.3
6.6
N.A.
93.3
93.3
N.A.
N.A.
26.6
26.6
26.6
N.A.
40
0
33.3
40
P-Site Similarity:
100
100
100
13.3
N.A.
100
100
N.A.
N.A.
46.6
46.6
66.6
N.A.
53.3
13.3
53.3
53.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
8
39
0
0
8
39
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
39
0
39
54
0
0
8
0
0
0
0
0
0
8
0
% D
% Glu:
0
31
54
16
31
16
70
0
0
16
39
0
0
0
0
% E
% Phe:
8
0
0
0
0
0
0
0
0
0
0
0
8
47
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
8
47
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
8
39
0
0
8
0
0
% H
% Ile:
31
0
0
0
47
0
0
8
8
0
0
39
0
0
16
% I
% Lys:
8
31
0
0
0
0
0
0
31
0
0
8
70
0
0
% K
% Leu:
0
0
0
0
0
0
0
0
0
0
0
0
0
39
0
% L
% Met:
8
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
8
39
0
31
8
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
8
85
% P
% Gln:
0
0
0
0
0
0
0
0
0
16
0
0
0
0
0
% Q
% Arg:
0
0
0
0
0
0
0
8
47
0
0
8
16
0
0
% R
% Ser:
0
0
0
0
0
0
0
47
0
0
8
0
0
0
0
% S
% Thr:
0
0
0
0
0
0
16
0
0
8
0
8
0
0
0
% T
% Val:
0
0
8
0
8
0
0
0
0
16
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
8
85
0
0
8
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _